KMID : 1161420120150110968
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Journal of Medicinal Food 2012 Volume.15 No. 11 p.968 ~ p.973
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Prickly Pear Cactus (Opuntia ficus indica var. saboten) Protects Against Stress-Induced Acute Gastric Lesions in Rats
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Kim Seung-Hyun
Jeon Byung-Ju Kim Dae-Hyun Kim Tae-Il Lee Hee-Kyoung Han Dae-Seob Lee Jong-Hwan Kim Tae-Bum Kim Jung-Wha Sung Sang-Hyun
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Abstract
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The protective activity of prickly pear cactus (Opuntia ficus indica var. saboten) fruit juice and its main constituent, betanin, were evaluated against stress-induced acute gastric lesions in rats. After 6?h of water immersion restraint stress (WIRS), gastric mucosal lesions with bleeding were induced in Sprague?Dawley rats. Pretreatment of a lyophilized powder containing O. ficus indica var. saboten fruit juice and maltodextrin (OFSM) and betanin significantly reduced stress lesions (800?1600?mg/kg). Both OFSM and betanin effectively prevented the decrease in gastric mucus content as detected by alcian blue staining. In addition, OFSM significantly suppressed WIRS-induced increases in the level of gastric mucosal tumor necrosis factor-¥á and myeloperoxidase (MPO). Betanin alone was only effective in decreasing MPO. These results revealed the protective activity of OFSM against stress-induced acute gastric lesions and that betanin may contribute to OFSM¡¯s gastric protective activity, at least in part. When OFSM and betanin were taken together, OFSM exerted gastroprotective activity against stress-induced gastric lesions by maintaining gastric mucus, which might be related to the attenuation of MPO-mediated damage and proinflammatory cytokine production.
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KEYWORD
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betanin, gastric lesion, Opuntia ficus indica var. saboten, water immersion restraint stress
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